Hydrogen Peroxide and Cell Signaling, Part C

Erscheinungsjahr 2013
ISBN: 978-0-12-405881-1
Verlag: William Andrew Publishing

Buch, Englisch, 384 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 760 g

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the third of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as the biological chemistry of hydrogen peroxide, reactive oxygen species in the activation of MAP kinases, and investigating the role of reactive oxygen species in regulating autophagy.

Zielgruppe

<p>Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists</p>

Autoren/Hrsg.

Weitere Mitwirkende

Cadenas, Enrique

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Physik Angewandte Physik Biophysik
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Angewandte Biologie Biophysik
• Naturwissenschaften Chemie Organische Chemie Biochemie

Inhaltsverzeichnis

-   - The Biological Chemistry of Hydrogen Peroxide

- Reactive Oxygen Species in the Activation of MAP Kinases

- Hydrogen Peroxide Signaling Mediator in the Activation of p38 MAPK in Vascular Endothelial Cells

- In vivo Imaging of Nitric Oxide and Hydrogen Peroxide in Cardiac Myocytes

- Methods for Studying Oxidative Regulation of Protein Kinase C

- P66Shc, Mitochondria and the Generation of Reactive Oxygen Species

- Detecting Disulfide Bound Complexes and the Oxidative Regulation of Cyclic Nucleotide Dependent Protein Kinases by H2O2

- Redox Regulation of Protein Tyrosine Phosphatases: Methods for Kinetic Analysis of Covalent Enzyme Inactivation

- Activation of Nrf2 by H2O2: De novo Synthesis versus Nuclear Translocation

- H2O2 in the Induction of NF-k B-Dependent Selective Gene Expression

- Detection of H2O2-Mediated Phosphorylation of Kinase-Inactive PDGFRa

- Genetic Modifier Screens to Identify Components of a Redox-Regulated Cell Adhesion and Migration Pathway

- Investigating the Role of Reactive Oxygen Species in Regulating Autophagy

- H2O2: A Chemoattractant?

- Measuring Mitochondrial Uncoupling Protein-2 Level and Activity in Insulinoma Cells

- Effects of H2O2 on Insulin Signaling and the Glucose Transport System in Mammalian Skeletal Muscle

- Monitoring of Hydrogen Peroxide and Other Reactive Oxygen and Nitrogen Species Generated by Skeletal Muscle

Über Autor(innen)

Cadenas, Enrique
ENRIQUE CADENAS, MD, PhD, received his PhD in biochemistry from the University of Buenos Aires, School of Medicine. He is professor of pharmacology and pharmaceutical sciences at the University of Southern California School of Pharmacy and of biochemistry and molecular biology at the University of Southern California Keck School of Medicine, and doctor honoris causa (medicine) at the University of Linköping, Sweden. Cadenas was president of the Society for Free Radical Research International (SFRRI) and is fellow of the Society for Free Radical Biology & Medicine. He served the scientific community by participating on NIH study sections (2002-2006; chair 2006-2008). His research interests include energy and redox metabolism in brain aging and the coordinated inflammatory-metabolic responses in brain and neurodegenerative diseases.