Ionizing Radiation and the Immune Response - Part A

Erscheinungsjahr 2023
ISBN: 978-0-323-95523-2
Verlag: William Andrew Publishing

Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 450 g

Ionizing Radiation and the Immune Response, Volume 376, Part A reviews the latest updates on the immune response induced by ionizing radiations. Sections discuss NK functions in radio-induced immune response, TRT and immune response, Radio-induced immune response and lipid metabolism, Effect of protons and heavy ions on immune response, Effect of flashtherapy and mini beam on immune response, Radio-induced lymphopenia, CT to potentiate radio-induced immune response, Impact of RT on healthy tissues (inflammation), Radio-induced macrophagic response, To use nanoparticles and ionizing radiations to modulate immune response: opinion of the chemist, biologist and clinician, and more.

Additional sections touch on the Effect of low dose radiation on radio-induced immune response, Role of Dendritic cells in radiation-induced immune response, Relationship between the tumor microenvironment and the efficacy of the radiotherapy/immunotherapy combination+A23, and Biomarkers of radiation induced response to optimize radio-immunotherapy combination.

Autoren/Hrsg.

Weitere Mitwirkende

Mirjolet, Celine

Fachgebiete

• Naturwissenschaften Biowissenschaften Molekularbiologie
• Naturwissenschaften Biowissenschaften Entwicklungsbiologie
• Naturwissenschaften Biowissenschaften Zellbiologie

Inhaltsverzeichnis

1. Are charged particles a good match for combination with immunotherapy? Current knowledge and perspectives

Helm, A., Totis, C., Durante, M. and Fournier, C.

2. Radiation-induced immune response in novel radiotherapy approaches FLASH and spatially fractionated radiotherapies

Annaig Bertho, Lorea Iturri and Yolanda Prezado

3. Impact of radiation therapy on healthy tissues

Cyrus Chargari, Elie Rassy, Carole Helissey, Samir Achkar, Sabine Francois and Eric Deutsch

4. The various functions and phenotypes of macrophages are also reflected in their responses to irradiation: A current overview

Lisa Deloch, Michael Rückert, Thomas Weissmann, Sebastian Lettmaier, Eva Titova, Teresa Wolff, Felix Weinrich, Rainer Fietkau and Udo S Gaipl

5. Fatty acid metabolism and radiation-induced anti-tumor immunity

Mara De Martino, Camille Daviaud, Edgar Hajjar and Claire Vanpouille-Box

6. Chemotherapy to potentiate the radiation-induced immune response

Benoît Lecoester, Mylène Wespiser, Amélie Marguier, Céline Mirjolet, Jihane Boustani and Olivier Adotévi

Über Autor(innen)

Mirjolet, Celine
Dr. Céline Mirjolet is a radiobiologist with in-depth knowledge of the impact of radiotherapy fractionation on the radiation-induced immune response and on the effectiveness of the radiotherapy and immunotherapy combination. She obtained a doctorate in radiobiology at the anti-cancer center of Nancy (France). She then moved to Brussels at the University of Belgium to study epigenetic mechanisms in transcriptional activity and cancer. For ten years, she has been working in the radiotherapy department of the Dijon cancer center in close collaboration with clinicians and physicists to develop translational research projects on the combination of immunotherapy and radiotherapy. She leads the preclinical research team in radiotherapy and radiobiology and her programs focus on the validation of preclinical concepts leading to the design of clinical trials.