Biomedical Applications of Acridines

Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases
1. Auflage 2017
ISBN: 978-3-319-63952-9
Verlag: Springer International Publishing

Buch, Englisch, Band 72, 237 Seiten, HC runder Rücken kaschiert, Format (B × H): 160 mm x 241 mm, Gewicht: 5029 g

Reihe: Progress in Drug Research

This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can  be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.

Zielgruppe

Research

Autoren/Hrsg.

Je¿ek, Jan

¿Ebestík, Jaroslav

Hlavácek, Jan

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft
• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Biowissenschaften Proteinforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft

Inhaltsverzeichnis

Preliminary ToC 1 Introduction.- 2 Nomenclature.- 3. Syntheses.- 4. Interactions of acridines with nucleic acids.- 5. Intercations with proteins.- 6. Applications for treament of neurodegenerative diseases.- 7. Some applications of selective toxicities of acridines.- 8. Acridine on dendrimeric carriers.- 9 Acridines used for staining.- 10 Miscellaneous.- 11 Conclusions and outlook.