Joule / Mills Heterocyclic Chemistry

5. Auflage 2010
ISBN: 978-0-470-68597-6
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 640 Seiten, E-Book

This book has so closely matched the requirements of itsreadership over the years that it has become the first choice forchemists worldwide.

Heterocyclic chemistry comprises at least half of all organicchemistry research worldwide. In particular, the vast majority oforganic work done in the pharmaceutical and agrochemical industriesis heterocyclic chemistry.

The fifth edition of Heterocyclic Chemistry maintains theprincipal objective of earlier editions - to teach thefundamentals of heterocyclic reactivity and synthesis in a way thatis understandable to second- and third-year undergraduate chemistrystudents. The inclusion of more advanced and current material alsomakes the book a valuable reference text for postgraduate taughtcourses, postgraduate researchers, and chemists at all levelsworking with heterocyclic compounds in industry.

Fully updated and expanded to reflect important 21stcentury advances, the fifth edition of this classic text includesthe following innovations:

* Extensive use of colour to highlight changes in structure andbonding during reactions

* Entirely new chapters on organometallic heterocyclic chemistry,heterocyclic natural products, especially in biochemical processes,and heterocycles in medicine

* New sections focusing on heterocyclic fluorine compounds,isotopically labeled heterocycles, and solid-phase chemistry,microwave heating and flow reactors in the heterocycliccontext

Essential teaching material in the early chapters is followed byshort chapters throughout the text which capture the essence ofheterocyclic reactivity in concise resumés suitable asintroductions or summaries, for example for examinationpreparation. Detailed, systematic discussions cover the reactivityand synthesis of all the important heterocyclic systems. Originalreferences and references to reviews are given throughout the text,vital for postgraduate teaching and for research scientists.Problems, divided into straightforward revision exercises, and morechallenging questions (with solutions available online), help thereader to understand and apply the principles of heterocyclicreactivity and synthesis.

Autoren/Hrsg.

Joule, John A.

Mills, Keith

Inhaltsverzeichnis

Preface
Definitions of abbreviations
1. Heterocyclic nomenclature
2. Structures and spectroscopic properties of aromaticheterocycles
3. Substitutions of aromatic heterocycles
4. Organometallic heterocyclic chemistry
5. Methods in heterocyclic chemistry
6. Ring synthesis of aromatic heterocycles
7. Typical reactivity of pyridines, quinolines andisoquinolines
8. Pyridines: reactions and synthesis
9. Quinolines and isoquinolines: reactions andsynthesis
10. Typical reactivity of pyrylium and benzopyrylium ions,pyrones and benzopyrones
11. Pyryliums, 2- and 4-pyrones: reactions andsynthesis
12. Benzopyryliums, benzopyrones: reactions andsynthesis
13. Typical reactivity of the diazines: pyridazine,pyrimidine and pyrazine
14. The diazines: pyridazine, pyrimidine, and pyrazine:reactions and synthesis
15. Typical reactivity of pyrroles, thiophenes, andfurans
16. Pyrroles: reactions and synthesis
17. Thiophenes: reactions and synthesis
18. Furans: reactions and synthesis
19. Typical reactivity of indoles, benzo[b]thiophenes,benzo[b]furans, isoindoles, benzo[c]thiophenes andisobenzofurans
20. Indoles: reactions and synthesis
21. Benzo[b]thiophenes and benzo[b]furans:reactions and synthesis
22. Isoindoles, benzo[c]thiophenes and isobenzofurans:reactions and synthesis
23. Typical reactivity of 1,3- and 1,2-azoles and benzo-1,3-and -1,2-azoles
24. 1,3-Azoles: imidazoles, thiazoles, and oxazoles:reactions and synthesis
25. 1,2-Azoles: pyrazoles, isothiazoles, isoxazoles:reactions and synthesis
26. Benzanellated azoles: reactions and synthesis
27. Purines: reactions and synthesis
28. Heterocycles containing a ring-junction nitrogen(bridgehead compounds)
29. Heterocycles containing more than two heteroatoms
30. Saturated and partially unsaturated heterocycliccompounds: reactions and synthesis
31. Special topics
32. Heterocycles in biochemistry; heterocyclic naturalproducts
33. Heterocycles in medicine

Über Autor(innen)

John Joule is Emeritus Professor in the School of Chemistry,The University of Manchester, UK
Keith Mills spent 25 years in the Medicinal Chemistry andDevelopment Chemistry departments at GlaxoSmithKline, Stevenage,UK, and is now an independent consultant.