Buch, Englisch, 350 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 730 g
Understanding Drug Response
Buch, Englisch, 350 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 730 g
ISBN: 978-0-12-803752-2
Verlag: William Andrew Publishing
Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization.
This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery.
Zielgruppe
Graduate students, new researchers and professors in pharmacology, as well as scientists (biologist or chemist) who foresee applying pharmacology to the discovery of new drug molecules from either industry or academic standpoints
Autoren/Hrsg.
Fachgebiete
Weitere Infos & Material
1. Pharmacology: The Chemical Control of Physiology2. Drug Affinity and Efficacy3. Predicting Agonist Effect4. Drug Antagonism: Orthosteric Drug Effects5. Allosteric Drug Effects6. Enzymes as Drug Targets7. Pharmacokinetics I: Permeation and Metabolism8. Pharmacokinetics II: Distribution and Multiple Dosing9. In Vivo Pharmacology10. Safety Pharmacology11. Pharmacology in Drug Discovery