Kenakin | Pharmacology in Drug Discovery | Buch | 978-0-12-384856-7 | sack.de

Buch, Englisch, 260 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 540 g

Kenakin

Pharmacology in Drug Discovery

Understanding Drug Response
Erscheinungsjahr 2011
ISBN: 978-0-12-384856-7
Verlag: William Andrew Publishing

Understanding Drug Response

Buch, Englisch, 260 Seiten, Format (B × H): 191 mm x 235 mm, Gewicht: 540 g

ISBN: 978-0-12-384856-7
Verlag: William Andrew Publishing


Pharmacology in Drug Discovery: Understanding Drug Response is designed for all students, recent graduates, and new researchers in the pharmaceutical and biotechnology industries who need to interpret change in physiology induced by a chemical substance. Physiological systems customize chemical signal input to their own needs; therefore the same drug can have different effects in different physiological systems. The field of pharmacology is unique in that it furnishes the tools to analyze these different behaviors and traces them to their root cause. This enables predictions of drug behavior to be made in all systems, an invaluable tool for drug discovery because almost all drugs are developed in test systems far removed from the therapeutic one. This valuable resource provides simple explanations of the ways in which biological systems use basic biochemical mechanisms to produce fine chemical control of physiology, allowing for more informed predictions of drug effects in all systems and forming the basis of the drug-discovery process. Chapters follow a logical progression on how to characterize the pharmacology of any given molecule, and include important terminology, chapter summaries, references, and review questions to aid the reader in understanding and retention of the material.
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Zielgruppe


Recent graduates and new researchers in the pharmaceutical and biotechnology industries


Autoren/Hrsg.


Weitere Infos & Material


Chapter 1: Pharmacology: The Chemical Control of Physiology

Chapter 2: Drug Affinity and Efficacy

Chapter 3: Predicting Agonist Effect

Chapter 4: Drug Antagonism: Orthosteric Drug Effects

Chapter 5: Allosteric Drug Effects

Chapter 6: Enzymes as Drug Targets

Chapter 7: Pharmacokinetics I: Permeation and Metabolism

Chapter 8: Pharmacokinetics II: Distribution and Multiple Dosing

Chapter 9: In Vivo Pharmacology

Chapter 10: Safety Pharmacology

Chapter 11: Answers to Chapter Questions

Chapter 12: Derivations and Proofs


Kenakin, Terry P.
Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.


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