Langman / Dasgupta Pharmacogenomics in Clinical Therapeutics

1. Auflage 2012
ISBN: 978-1-119-95958-8
Verlag: John Wiley & Sons
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 400 Seiten, E-Book

Pharmacogenomics is the basis of personalized medicine which willbe the medicine of the future. Through both reducing the numbers ofadverse drug reactions and improving the use of existing drugs intargeted populations, pharmacogenomics represents a real advance ontraditional therapeutic drug monitoring.

Pharmacogenomics in Clinical Therapeutics provides anintroduction to the principles of pharmacogenomics beforeaddressing the pharmacogenomic aspects of key therapeutic areassuch as warfarin therapy, cancer chemotherapy, therapy withimmunosuppressants, antiretroviral therapy, and psychoactive drugs.It also includes methods of pharmacogenomic testing and thepharmacogenomic aspects of drug-drug interactions.

From a team of expert contributors, Pharmacogenomics inClinical Therapeutics is a comprehensive overview of thecurrent state of pharmacogenomics in pharmacotherapy for allclinicians, pharmacologists and clinical laboratory professionals.It is also a guide for practicing clinicians and health careprofessionals to the basic principles of pharmacogenomics,laboratory tests currently available to aid clinicians, and thefuture promise of this developing field.

Autoren/Hrsg.

Langman, Loralie J.

Dasgupta, Amitava

Inhaltsverzeichnis

List of Contributors, vii
Preface, ix
1 Pharmacogenomics Principles: Introduction to PersonalizedMedicine, 1
Parvaz Madadi, PhD and Gideon Koren, MD
2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics:Are They Complementary? 15
Christine L.H. Snozek, PhD, Loralie J. Langman, PhD, and AmitavaDasgupta, Ph.D
3 Pharmacogenomics Aspect of Warfarin Therapy, 26
Matthew D. Krasowski, MD, PhD
4 Pharmacogenetics and Cancer Chemotherapy, 39
Christine L.H. Snozek
5 Pharmacogenomic Considerations in Anesthesia and PainManagement, 53
Christine M. Formea, PharmD and Wayne T. Nicholson, MD,PharmD
6 Pharmacogenomics of Immunosuppressants, 70
Nicolas Picard, PharmD, PhD and Pierre Marquet, MD, PhD
7 Pharmacogenomics of Cardiovascular Drugs, 98
Linnea M. Baudhuin, PhD
8 Pharmacogenomic Aspects of Antiretroviral Therapy, 127
Natella Y. Rakhmanina, MD, PhD and John N. van den Anker, MD,PhD
9 Pharmacogenetics of Psychoactive Drugs, 144
Jorge L. Sepulveda, MD, PhD
10 Pharmacogenomic Aspects of Adverse Drug-DrugInteractions, 176
Loralie J. Langman, PhD and Christine L.H. Snozek, PhD
11 Microarray Technology and Other Methods in PharmacogenomicsTesting, 185
Jorge L. Sepulveda, MD, PhD
12 Pharmacogenetic Testing in the Clinical LaboratoryEnvironment, 201
Mark P. Borgman, PhD and Mark W. Linder, PhD
Index, 225