Bioinformatics and Drug Discovery

2. Auflage 2012
ISBN: 978-1-61779-964-8
Verlag: Humana Press

Buch, Englisch, Band 910, 374 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 925 g

Reihe: Methods in Molecular Biology

Recent advances in drug discovery have been rapid.  The second edition of  Bioinformatics and Drug Discovery has been completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter,  detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition  seeks to aid scientists in the further study of the rapidly expanding field of drug discovery.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Larson, Richard S.

Fachgebiete

• Naturwissenschaften Biowissenschaften Proteinforschung
• Mathematik | Informatik EDV | Informatik Angewandte Informatik Bioinformatik
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Naturwissenschaften Biowissenschaften Angewandte Biologie Bioinformatik
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

1. Cell Perturbation Screens for Target Identification by RNAi
Kubilay Demir and Michael Boutros
 
2. Using Functional Genomics to Identify Drug Targets: a Dupuytren’s Disease Example
Mirela Sedic, Sandra Kraljevic Pavelic, Karlo Hock
 
3. Functional Characterization of Human Genes from Exon Expression and RNA Interference ResultsDorothea Emig, Hagen Blankenburg, Fidel Ramírez, and Mario Albrecht 
4. Barcode Sequencing for Understanding Drug-gene Interactions
Andrew M. Smith, Tanja Durbic, Saranya  Kittanakom, Guri Giaever, Corey Nislow
 
5. High-Throughput Sequencing of the Methylome Using Two-Base Encoding
Christina A. Bormann Chung
 
6. Applications and Limitations of In Silico Models In Drug Discovery
Ahmet Secan, Sean Ekins, and Sandhya Kortagere
 
7. Compound Collection Preparation for Virtual ScreeningCristian G. Bologa and Tudor I. Oprea
 
8. Mapping Between Databases of Compounds and Protein Targest
Sorel Muresan, Markus Sitzmann, and Christopher Southan
 
9. Predictive Cheminformatics in Drug Discovery: Statistical Modeling for Analysis of Micro-Array and Gene Expression Data
N. Sukumar, Michael P. Krein, Mark J. Embrechts 
10. Advances in Nuclear Magnetic Resonance for Drug Discovery
Laurel O. Sillerud, and Richard S. Larson 
11. Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug Resistance
Toshihisa Ishikawa, Hikaru Saito, Hiroyuki Hirano, Yutaka Inoue, Yoji Ikegami 
12. Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and Selection
Javier De Las Rivas and Carlos Prieto
 
13. Linking Variants from Genome-Wide Association Analysis to Function via Transcriptional Network AnalysisBenjamin J. Keller, Sebastian Martini, Viji Nair
 
14. Models of Excitation-Contraction Coupling in Cardiac Ventricular Myocytes
M. Saleet Jafri
 
15. Integration of Multiple Ubiquitin Signals in Proteasome Regulation
Marta Isasa, Alice Zuin and Bernat Crosas
 

 
4. Barcode Sequencing for Understanding Drug-gene Interactions
Andrew M. Smith, Tanja Durbic, Saranya  Kittanakom, Guri Giaever, Corey Nislow
 
5. High-Throughput Sequencing of the Methylome Using Two-Base Encoding
Christina A. Bormann Chung
 
6. Applications and Limitations of In Silico Models In Drug Discovery
Ahmet Secan, Sean Ekins, and Sandhya Kortagere
 
7. Compound Collection Preparation for Virtual ScreeningCristian G. Bologa and Tudor I. Oprea
 
8. Mapping Between Databases of Compounds and Protein Targest
Sorel Muresan, Markus Sitzmann, and Christopher Southan
 
9. Predictive Cheminformatics in Drug Discovery: Statistical Modeling for Analysis of Micro-Array and Gene Expression Data
N. Sukumar, Michael P. Krein, Mark J. Embrechts 
10. Advances in Nuclear Magnetic Resonance for Drug Discovery
Laurel O. Sillerud, and Richard S. Larson 
11. Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug Resistance
Toshihisa Ishikawa, Hikaru Saito, Hiroyuki Hirano, Yutaka Inoue, Yoji Ikegami 
12. Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and Selection
Javier De Las Rivas and Carlos Prieto
 
13. Linking Variants from Genome-Wide Association Analysis to Function via Transcriptional Network AnalysisBenjamin J. Keller, Sebastian Martini, Viji Nair
 
14. Models of Excitation-Contraction Coupling in Cardiac Ventricular Myocytes
M. Saleet Jafri
 
15. Integration of Multiple Ubiquitin Signals in Proteasome Regulation
Marta Isasa, Alice Zuin and Bernat Crosas
 

 
10. Advances in Nuclear Magnetic Resonance for Drug Discovery
Laurel O. Sillerud, and Richard S. Larson 
11. Human ABC Transporter ABCG2 in Cancer Chemotherapy: Drug Molecular Design to Circumvent Multidrug Resistance
Toshihisa Ishikawa, Hikaru Saito, Hiroyuki Hirano, Yutaka Inoue, Yoji Ikegami 
12. Protein Interactions: Mapping Interactome Networks to Support Drug Target Discovery and Selec