Handbook of Neurotoxicology

Volume II
2002
ISBN: 978-0-89603-796-0
Verlag: Humana Press

Buch, Englisch, 594 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 1495 g

N eurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, 1ead, mercury, and the polytypic byproducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins ofbroadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentalIy by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor­ of some neurotoxicants of anthropogenic ori­ tunately, the environmental accumulation gin, expecialIy pesticides and metals, has resulted in incidents ofhuman poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the re suit of increased vigi­ lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxicants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.

Zielgruppe

Research

Autoren/Hrsg.

Massaro, Edward J.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

1 Developmental Neurotoxicology: Testing and Interpretation.- 2 Manifestations of CNS Insult During Development.- 3 Developmental Neurotoxicity: What Have We Learnedfrom Guideline Studies?.- 4 Risk Assessment of Developmental Neurotoxicants.- 5 Electrophysiologic Evidence of Neural Injury or Adaptation in Cocaine Dependence.- 6 Addictive Basis of Marijuana and Cannabinoids.- 7 Dopamine and Its Modulation of Drug-Induced Neuronal Damage.- 8 NMDA Antagonist-Induced Neurotoxicity and Psychosis: The Dissociative Stimulation Hypothesis.- 9 Emerging Drugs of Abuse: Use Patterns and Clinical Toxicity.- 10 Mechanisms of Methamphetamine-Induced Neurotoxicity.- 11 Neurotoxic Effects of Substituted Amphetamines in Rats and Mice: Challenges to the Current Dogma.- 12 Studies of Neural Degeneration Indicate that Fasciculus Retroflexus Is a Weak Link in Brain for Many Drugs of Abuse.- 13 Microsensors Detect Neuroadaptation by Cocaine: Serotonin Released in Motor Basal Ganglia Is Not Rhythmicwith Movement.- 14 Impact of Intoxication: Structural and Functional Modificationsin the Brain Induced by Ethanol Exposure.- 15 Structural and Functional Neuroimaging of the Effects of Opioids.- 16 Structural and Functional Neuroimaging of the Effects of Cocaine in Human and Nonhuman Primates.- 17 Functional Neuroimaging of Cannabinoid Effects.- 18 Neuroimaging of MDMA-Induced Neurotoxicity.- 19 Tier 1 Neurological Assessment in Regulated Animal Safety Studies.- 20 Neurological Assessment: The Role of the Clinicianin Clinical Neurotoxicology.- 21 Human Neuropsychological Testing and Evaluation.