Scaffolds for Tissue Engineering

1. Auflage 2014
ISBN: 978-981-4463-20-1
Verlag: Pan Stanford

Buch, Englisch, 698 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 1088 g

Scaffolds for tissue engineering are devices that exploit specific and complex physical and biological functions, in vitro or in vivo, and communicate through biochemical and physical signals with cells and, when implanted, with the body environment. Scaffolds are produced mainly with synthetic materials, and their fabrication technologies are derived from already well-established industrial processes, with some new specific technologies having been developed in the last years to address required complexities.

Often, a generalist approach is followed for the translation of materials and technologies designed for other applications, without considering the specific role of scaffolds from a physical and biological point of view. The book illustrates scaffold design principles, with particular relevance to the biological requirements needed to control and drive the biological cross talk, and reviews materials and fabrication and validation methods.

Zielgruppe

Academic and Postgraduate

Autoren/Hrsg.

Migliaresi, Claudio

Motta, Antonella

Fachgebiete

• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Biotechnologie Medizinische Biotechnologie
• Naturwissenschaften Biowissenschaften Biowissenschaften

Inhaltsverzeichnis

Preface, 1 Overview: An Evolving State of the Art in Tissue Engineering, 2 The Functional Role of Extracellular Matrix, 3 The Premise of Tissue Engineering: Molecular Recognition, 4 Principles and Biological Pathways to Tissue Regeneration: The Tissue Regenerative Niche, 5 Host Response to Biomaterials, 6 Scaffold Vascularization, The Role of Osteoblasts in in vitro Vascularization, 7 Engineering Biomimetic Scaffolds, 8 Biomaterials for Scaffolds: Synthetic Polymers, 9 Biomaterials for Scaffolds: Natural Polymers, 10 Hydrogels: Characteristics and Properties, Protein-Based Hydrogels, 11 Fabrication Methods of Tissue Engineering Scaffolds, 12 Engineered Scaffolds: Materials and Microstructure from Nanostructures to Macrostructures for Tissue Engineering, Decellularized Tissues as Scaffolds, 13 Organ Printing and Cell Encapsulation, 14 In vitro and in vivo Testing, 15 Bioreactor Strategies for in vitro Conditioning of Engineered Tissues, 16 Microvascular Imaging Methods for Tissue Engineering, 17 Tissue Engineering: Scope, Products, and Commercialization Strategies

Über Autor(innen)

Claudio Migliaresi is professor of composite materials engineering and of biomaterials and biomedical technologies, head of the Department of Industrial Engineering, dean of the School of Industrial Engineering, and head of the BIOtech Research Center of the University of Trento, Italy. His research activities range from composite materials to biodegradable polymers, biomaterials, materials, and scaffolds for tissue engineering. Prof. Migliaresi has published about 200 papers, edited the five volumes of the book Polymers in Medicine, and owns some patents.

Antonella Motta is assistant professor at the University of Trento and has qualified as associate professor of bioengineering by the Italian evaluation system. She teaches bioengineering and tissue engineering and regenerative medicine courses. Prof. Motta’s research activities are mainly focused on nature-derived polymers for tissue engineering applications, scaffold design, and interactions of material–biological systems. She has published about 90 papers, edited several chapters on tissue engineering, and owns some patents.