Niwa Uremic Toxins

1. Auflage 2012
ISBN: 978-1-118-42408-7
Verlag: John Wiley & Sons
Format: PDF
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 400 Seiten, E-Book

Reihe: Wiley-Interscience Series on Mass Spectrometry

Reviews all the latest basic and clinical researchfindings
With contributions from leading international experts in thefield, this book is dedicated to all facets of uremic toxinsresearch, including low molecular weight solutes, protein-boundsolutes, and middle molecules. Moreover, it covers everything frombasic mass spectrometry research to the latest clinical findingsand practices.
Uremic Toxins is divided into three sections:
* Section One, Uremic Toxins, explores the definition,classification, listing, and mass spectrometric analysis of uremictoxins
* Section Two, Selected Uremic Toxins, describes keyuremic toxins, explaining chemical structures, metabolism,analytical methods, plasma levels, toxicity, clinical implications,and removal methods. Among the uremic toxins covered are indoxylsulfate, asymmetric dimethylarginine, PTH, ß2-microglobulin,and AGEs
* Section Three, Therapeutic Removal of Uremic Toxins,describes how uremic toxins can be removed by hemodialysis,peritoneal dialysis, and oral sorbent
All chapters are based on the authors' thorough review of theliterature as well as their own personal laboratory and clinicalexperience. References at the end of each chapter provide a gatewayto the literature in the field.
Reviewing all the latest basic and clinical research findings,Uremic Toxins will help bench scientists in nephrologyadvance their own investigations. It will also help clinicians takeadvantage of the latest tested and proven treatments for themanagement of chronic kidney disease.

Autoren/Hrsg.

Niwa, Toshimitsu

Inhaltsverzeichnis

PREFACE ix
CONTRIBUTORS xi
SECTION 1: UREMIC TOXINS 1
1. Uremic Toxins: An Integrated Overview of Definition andClassification 3
Richard J. Glassock and Shaul G. Massry
2. Classification and a List of Uremic Toxins 13
Nathalie Neirynck, Rita De Smet, Eva Schepers, RaymondVanholder, and Griet Glorieux
3. Analysis of Uremic Toxins with Mass Spectrometry 35
Toshimitsu Niwa
SECTION 2: SELECTED UREMIC TOXINS 51
4. Indoxyl Sulfate 53
Toshimitsu Niwa
5. p-Cresyl Sulfate 77
Anneleen Pletinck, Raymond Vanholder, and Griet Glorieux
6. 3-Carboxy-4-methyl-5-propyl-2-furanpropionic Acid 87
Toshimitsu Niwa
7. Phenylacetic Acid 99
Anna Schulz and Joachim Jankowski
8. Homocysteine and Hydrogen Sulfide, Two Opposing Aspects inthe Pathobiology of Sulfur Compounds in Chronic Renal Failure109
Alessandra F. Perna and Diego Ingrosso
9. Guanidino Compounds 125
Sunny Eloot, Griet Glorieux, Peter Paul De Deyn, and RaymondVanholder
10. Asymmetric Dimethylarginine 143
Vladimyr Teplan and Jaroslav Racek
11. Nicotinamide Metabolites 163
Boleslaw Rutkowski and Przemyslaw Rutkowski
12. Dicarbonyls (Glyoxal, Methylglyoxal, and 3-Deoxyglucosone)177
Naila Rabbani and Paul J. Thornalley
13. Glucose Degradation Products in Peritoneal Dialysis193
Monika Pischetsrieder and Sabrina Gensberger
14. Dinucleoside Polyphosphates 209
Joachim Jankowski and Vera Jankowski
15. Parathyroid Hormone 227
Shaul G. Massry and Miroslaw Smogorzewski
16. b2-Microglobulin 249
Suguru Yamamoto, Junichiro James Kazama, Hiroki Maruyama, IchieiNarita, and Fumitake Gejyo
17. Cytokines 259
BjEURorn Anderstam, Bengt Lindholm, and PeterStenvinkel
18. Free Immunoglobulin Light Chains 279
Gerald Cohen and Walter H. HEURorl
19. Advanced Glycation Endproducts (AGEs) 293
Naila Rabbani and Paul J. Thornalley
20. Oxidized Albumin 305
Maurizio Bruschi, Giovanni Candiano, Laura Santucci, and GianMarco Ghiggeri
SECTION 3: THERAPEUTIC REMOVAL OF UREMIC TOXINS 315
21. Therapeutic Removal of Uremic Toxins by Hemodialysis317
Tammy L. Sirich, Pavel Aronov, and Timothy W. Meyer
22. Therapeutic Removal of Uremic Toxins by Peritoneal Dialysis331
Malgorzata Debowska, Elvia Garcya-Lopez, Jacek Waniewski, andBengt Lindholm
23. Therapeutic Removal of Uremic Toxins by Oral Sorbent359
Toshimitsu Niwa
INDEX 373

Über Autor(innen)

TOSHIMITSU NIWA, MD, PhD, is Professor in the Departmentof Advanced Medicine for Uremia at the Nagoya University GraduateSchool of Medicine. President of the Japanese Society forBiomedical Mass Spectrometry, Dr. Niwa has received many honors forhis research, including the Kimoto Prize of the Japanese Societyfor Dialysis Therapy and the International Society of UremiaResearch and Toxicity Award. He has published more than 300articles in peer-reviewed journals.