Oligomerization in Health and Disease

Erscheinungsjahr 2013
ISBN: 978-0-12-386931-9
Verlag: William Andrew Publishing

Buch, Englisch, 656 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 910 g

This special volume of Progress in Molecular Biology and Translational Science focuses on oligomerization in health and disease.

Zielgruppe

<p>Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.</p>

Autoren/Hrsg.

Weitere Mitwirkende

Giraldo, Jesus

Ciruela, Francisco

Fachgebiete

• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Biochemie (med.)

Inhaltsverzeichnis

Section I. Structural, Physico-Chemical, and Evolutionary Aspects of Protein Oligomerization

- Evolutionary, Physico-Chemical and Functional Mechanisms of Protein Homooligomerization

- Structural, Evolutionary and Assembly Principles of Protein Oligomerization

- Physico-Chemical Principles of Protein Aggregation

- Structural Aspects of Amyloid Formation

Section II. Oligomerization in Seven-Transmembrane Receptors

- Quaternary Structure Predictions and Structural Communication Features of GPCR Dimers

- Challenges in the Development of Heteromer-GPCR-Based Drugs

- Oligomerization of GPCRs in Health and Disease on "Di/Oligomerisation of GPCRS; Mechanisms and Functional Significance"

- G Protein-Coupled Receptor Heterocomplexes in Neuropsychiatric Disorders

- Disease-Specific Heteromerization of G Protein-Coupled Receptors that Target Drugs of Abuse

Section III. Oligomerization in Ion Channels

- Social Networking among Voltage-Gated Potassium Channels

- Oligomerization of the Mitochondrial Protein VDAC1: From Structure to Function and Cancer Therapy

- Consequences of Dimerization of the Voltage Gated Proton Channel

- Receptor Heteromeric Assembly, How it Works and Why it Matters - The Case of Ionotropic Glutamate Receptors

Section IV. Oligomerization in Enzymes

- The Structural Basis for the Allosteric Regulation of Ribonucleotide Reductase

- Oligomerization of Dynamin Superfamily Proteins in Health and Disease

- Multimerization of the Dnmt3a DNA Methyltransferase and its Functional Implications

- Oligomerization in Endoplasmic Reticulum Stress Signaling

Section V. Oligomerization in Regulatory Proteins

- Toll-IL-1-Receptor-Containing Adaptor Molecule-1 (TICAM-1), a Signaling Adaptor Linking Innate Immunity to Adaptive Immunity

- Assembly of Gamma-Tubulin Ring Complexes: Implications for Cell Biology and Disease

- Chemokine Oligomerization in Cell Signaling and Migration

- Oligomerization of Rab/Effector Complexes in the Regulation of Vesicle Trafficking

Über Autor(innen)

Giraldo, Jesus
Dr.Jesús Giraldo currently teaches at Universitat Autònoma de Barcelona in Barcelona, Spain.

Ciruela, Francisco
Dr. Francisco Ciruela currently teaches at University of Barcelona, Barcelona, Spain.