Ir Genes

Past, Present, and Future
1983
ISBN: 978-1-4612-5635-9
Verlag: Humana Press

Buch, Englisch, Band 4, 622 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 972 g

Reihe: Experimental Biology and Medicine

The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man­ uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad­ dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob­ servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog­ ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev­ eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.

Zielgruppe

Research

Autoren/Hrsg.

Pierce, Carl W.

Cullen, Susan E.

Shreffler, Donald C.

Kapp, Judith A.

Schwartz, Benjamin D.

Inhaltsverzeichnis

Genetic Organization of I-Region Genes.- Chemistry of I-Region Gene Products and DNA Cloning of I-Region Gene Products.- Ir Gene Function: Cellular Site(s) and Mechanism(s) of Action.- The Role of Ia Antigens in Restricted Cell Interactions.- Lessons on Ir Genes Derived from T Cell Clones and T Cell Hybridomas.- Where From Here?.