Protein-Protein Interactions in Human Disease, Part A

Erscheinungsjahr 2018
ISBN: 978-0-12-814344-5
Verlag: William Andrew Publishing

Buch, Englisch, 288 Seiten, Format (B × H): 152 mm x 229 mm, Gewicht: 610 g

Protein-Protein Interactions in Human Disease, Part A, Volume 110 aims to promote further research and development in the protein interaction network as a means to not only identify the critical proteins involved in the etiology of human diseases, but also identify new protein targets for drug development. Sections cover such topics as protein-protein interaction modulators for epigenetic therapies, intrinsic disorder, protein-protein interactions and disease, targeting protein-protein interactions in the ubiquitin-proteasome pathway, the proteomics of occupational diseases, and computational methods in predicting the impact of SNPs in protein-protein network, amongst other topics.

Zielgruppe

The aim of this volume is to promote further research and development in the protein interaction network in order to identify critical proteins involved in the etiology of human diseases and to identify new protein targets for drug development. Thus, this volume would be of considerable interest to protein chemists, pharmacologists, cell biologists, immunologists, structural biologists, computational biochemists and other researchers working in this field. Articles published here would also be of a great benefit to medical, biology and pharmacology students specializing in this field.

Autoren/Hrsg.

Weitere Mitwirkende

Donev, Rossen

Fachgebiete

• Naturwissenschaften Biowissenschaften Proteinforschung
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

1. Analysis of protein interactions by surface plasmon resonance Dennis G. Drescher 2. Using TR-FRET to investigate protein-protein interactions: a case study of PXR-coregulator interaction Taosheng Chen 3. Protein-Protein Interaction Modulators for Epigenetic Therapies Jose L. Medina-Franco 4. Intrinsic disorder, protein-protein interactions and disease Vladimir N. Uversky 5. Targeting protein-protein interactions in the ubiquitin-proteasome pathway Maria Gaczynska 6. Protein-protein networks involved in MODY family George Priya Doss P. C 7. Defining HIV-1 replication mechanisms by analyzing virus-host protein interactions Manuel Llano 8. Proteomics of occupational diseases Nicola Luigi Bragazzi 9. Proteomics of sport-related injuries Nicola Luigi Bragazzi 10. Structural prediction of protein-protein interactions by docking: application to biomedical problems Juan Fernandez-Recio 11. Computational methods in predicting the impact of SNPs in Protein-protein network George Priya Doss P. C

Über Autor(innen)

Donev, Rossen
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.