Studies in Natural Products Chemistry

Stereoselective Synthesis
Erscheinungsjahr 1993
ISBN: 978-0-444-89366-6
Verlag: Elsevier Science & Technology

Buch, Englisch, 540 Seiten, Gewicht: 1140 g

Studies in Natural Products Chemistry Volume 12: Stereoselective Synthesis (Part H) reviews the stereoselective synthetic and mechanistic chemistry of bicyclomycin. It discusses chemical studies of the taxane diterpenes; the synthetic methodology for 2-amino alcohols of biological interest; and the synthesis and structure of hydroxylated indolizidines. Some of the topics covered in the book are the synthetic routes to the oxahydrindene subunit of the avermectin-milbemycin family of antiparasitic agents; isolation, structure elucidation, biosynthesis, and biological activity of the avermectins; two-stage coupling process of macrolide antibiotics synthesis; and synthesis of the rifamycin S ansa-chain compound. The complete synthesis of erythromycin A is also covered. The role of isocyanides in the synthesis of beta lactam antibiotics and the characteristics of the beta lactam antibiotics are discussed. The development of an A-Ring annulation strategy for taxane synthesis is also presented. A chapter is devoted to the advances in the synthesis of tumor-promoting diterpenes. The book can provide useful information to chemists, biologists, students, and researchers.

Autoren/Hrsg.

Rahman, Atta-ur

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Technische Wissenschaften Verfahrenstechnik | Chemieingenieurwesen | Biotechnologie Pharmazeutische Technologie
• Naturwissenschaften Chemie Organische Chemie Biochemie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie

Inhaltsverzeichnis

Preface

Foreword

Contributors

Synthetic Routes to the Oxahydrindene Subunit of the Avermectinmilbemycin Family of Antiparasitic Agents: A Review

A New Tandem Process and its Application to the Syntheses of Macrolide Antibiotics

Stereoselective Synthetic and Mechanistic Chemistry of Bicyclomycin

The Role of Isocyanides in the Synthesis of ß-Lactam Antibiotics and Related Compounds

Synthesis of the 1ß-Methylcarbapenem Key Intermediates

Chemical Studies of the Taxane Diterpenes

Recent Advances in the Synthesis of Tumor-Promoting Diterpenes

Hydroxylated Indolizidines and Their Synthesis

A Survey of Indolo [2,3-a] Carbazole Alkaloids and Related Natural Products

Synthetic Methodology For 2-Amino Alcohols of Biological Interest

Stereoselective Synthesis of Natural Products Via Cationic and Radical Intermediates

Subject Index

Über Autor(innen)

Rahman, Atta-ur
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.