Excitatory Amino Acids

From Genes to Therapy
Softcover Nachdruck of the original 1. Auflage 1998
ISBN: 978-3-662-03598-6
Verlag: Springer

Buch, Englisch, Band 23, 210 Seiten, Paperback, Format (B × H): 148 mm x 210 mm, Gewicht: 296 g

Reihe: Ernst Schering Foundation Symposium Proceedings

In this book emerging questions of current glutamate research are addressed and new pathways which glutamte research may take in the future discussed. Since glutamate antagonists are still the major hope for the therapy of neurodegenerative disorders in humans, research activities dedicated towards the development of such novel drugs are the focus of public attention. The book comments on the most recent discoveries in the field of neuroprotection and neurodegeneration.

Zielgruppe

Research

Autoren/Hrsg.

Seeburg, Peter H.

Turski, Lechoslaw

Bresink, Iris

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Biomedizin, Medizinische Forschung, Klinische Studien

Inhaltsverzeichnis

1 Glutamate Receptor Channels, RNA Editing, and Epilepsy.- 2 Regulation of Glutamate Receptor Gene Expression in Global Ischemia.- 3 Factors Regulating Excitotoxic Neurodegeneration: The Role of Calcium and the Mitochondria.- 4 Excitotoxicity, Genetics, and Neurodegeneration in Amyotrophic Lateral Sclerosis.- 5 NO-NMDA Receptor Interactions: A Neuromolecular Approach to Novel Therapeutics.- 6 Glutamate in Neurodegenerative Disorders: Phenotype Resulting from Decreased Expression of AMPA Receptor GIuR-B Subunit mRNA in Rats.- 7 Quantitative Estimation of NMDA Receptor-Mediated Ca2+ Entry in Central Neurons.- 8 Calcium Permeability of Glutamate-Gated Channels in the CNS: Functional Role of the Ca2+-Permeable AMPA Receptor Channels.- 9 Localisation and Surface Expression of the AMPA Receptor Subunit GluR1 Using Green Fluorescent Protein and Anti-Peptide Antibodies.- 10 Input- and Output-Specific Segregation of Amino Acid Neurotransmitter Receptors on the Surface of Central Neurones.- Previous Volumes Published in this Series.