Diabetes & C-Peptide

Scientific and Clinical Aspects
2012
ISBN: 978-1-61779-390-5
Verlag: Humana Press

Buch, Englisch, Band 0, 169 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 555 g

Reihe: Contemporary Diabetes

In Diabetes & C-Peptide: Scientific and Clinical Aspects, a renowned group of leading researchers and physicians offers a comprehensive overview of the role of C-Peptide in type 1 diabetes. The book is organized in five sections. An Introductory section provides the background and key features of C-peptide’s physiological function and how its deficiency contributes to complications. The second section describes up-to-date information on the biochemical and molecular actions of C-peptide, including membrane binding, interactions with insulin as well as the interaction between C-peptide and zinc and effects on microvascular vasoreactivity. The third section summarizes in vivo animal studies of the type 1 diabetic complications. The fourth section reviews the clinical efforts of C-peptide on inflammation, cardiovascular complication, neuropathy and nephropathy. Finally, in the Conclusions section, a summary of the present state of C-peptide, outstanding questions, and the likely direction of the field are offered. Developed by the foremost investigators in the rapidly moving field of C-peptide research, Diabetes & C-Peptide: Scientific and Clinical Aspects is an important contribution to the literature for all researchers and physicians concerned about type 1 diabetes.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Sima, Anders A. F.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Diabetologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Stoffwechselstörungen
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Innere Medizin

Inhaltsverzeichnis

Preface.- Foreword.- C-peptide and Insulin – A Happy Marriage.- Peptide Interactions of Proinsulin C-peptide.- he Effect of Combined C-peptide and Zinc on Cellular Function.- C-Peptide Signaling in the Kidney and Protection from Diabetic Nephropathy.- Role of C-Peptide in the Regulation of Microvascular Blood Flow.- Is NO-eNOS a target for C-peptide action and its protective effects on diabetic nephropathy?.- Renoprotective Effects of C-Peptide in Type I Diabetes.- The Mechanisms Underlying the Effects of C-peptide on Type I Diabetic Neuropathy.- C-peptide and Type 1 Diabetic Encephalopathy.- C-peptide: a New Molecule with Anti-Inflammatory Properties.- C-peptide: Connecting Diabetes with Macrovascular Complications.- C-peptide and Diabetic Neuropathy in Patients with Type I Diabetes.- Proatherogenic Effects of C-Peptide.- Conclusions and Future Outlook.