LC-MS in Drug Analysis

Methods and Protocols
2012
ISBN: 978-1-61779-933-4
Verlag: Humana Press

Buch, Englisch, Band 902, 224 Seiten, Format (B × H): 183 mm x 260 mm, Gewicht: 649 g

Reihe: Methods in Molecular Biology

Liquid-Chromatography-Mass-Spectrometry procedures have been shown to be successful when applied to drug development and analysis. LC-MS in Drug Analysis: Methods and Protocols provides detailed LC-MS/MS procedures for the analysis of several compounds of clinical significance.  The first chapters provide the reader with an overview of mass spectroscopy, its place in clinical practice, its application of MS to TDM and toxicology, and the merits of LC-MS(/MS) and new sample preparation techniques.  The following chapters discuss different approaches to screening for drugs of abuse and for general unknowns, as well as targeted measurement of specific analytes or classes of analytes including abused drugs, toxic compounds, and therapeutic agents.  Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

 

Authoritative and easily accessible, LC-MS in Drug Analysis: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Snozek, Christine L. H.

Langman, Loralie J.

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie
• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Pharmazie
• Naturwissenschaften Chemie Analytische Chemie Instrumentelle Analytik, Chromatographie
• Naturwissenschaften Chemie Analytische Chemie Massenspektrometrie, Spektroskopie, Spektrochemie

Inhaltsverzeichnis

1. An Introduction to Drug Testing – The Expanding Role of Mass Spectrometry
            Catherine Hammett-Stabler and Steven W. Cotton
 
2. LC-MS vs. GC-MS, Online Extraction Systems, Advantages of Technology for Drug Screening Assays
            Pierre Marquet
 
3. LC-MS/MS Techniques for High Volume Screening of Drugs of Abuse and Target Drug Quantitation in Urine/Blood Matrices            Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay
 
4. Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry
            Cynthia L. Morris-Kukoski, Jason E. Schaff, and Louis J. Reda
 
5. Opiate Screening and Quantitation in Urine/Blood Matrices using LC-MS/MS Techniques
            Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay
 
6. Synthetic Opioid Analysis by LC-MS/MS
            David M. Garby and Lynn A. Cheryk
 
7. The Determination of Cannabinoids Using Liquid Chromatography with Mass Spectrometric Detection
            Oscar Quintela and Dennis J. Crouch
 
8. Cocaine and Metabolites by LC-MS/MS
            Christine L. H. Snozek, Matthew W. Bjergum, and Loralie J. Langman
 
9. Quantitation of Amphetamine Type Stimulants by LC-MS/MS
            Robert A. Middleberg and Joseph Homan
 
10. Detection of Prohibited Substances by Liquid Chromatography Tandem Mass Spectrometry for Sports Doping Control
            Brian D. Ahrens, Borislav Starcevic, and Anthony W. Butch
 
11. LC-MS/MS Screen for Xenobiotics and Metabolites
            François-Ludovic Sauvage and Pierre Marquet
 
12. Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS
            Robert A. Middleberg and Joseph Homan
 
13. Hypoglycemic Agent Screening by LC-MS/MS
            Eric W. Korman, Loralie J. Langman, and Christine L. H. Snozek
 
14. LC-MS/MS Method for the Detection of Common Laxatives
            Robert A. Middleberg and Joseph Homan
 
15. Simultaneous Determination of Cyclosporine, Sirolimus and Tacrolimus in Whole Blood Using Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS)
            Uttam Garg, Ada Munar, and C. Clinton Frazee III
 
16. Quantification of Tricyclic Antidepressants Using UPLC-MS/MS
            Kamisha L. Johnson-Davis, JoEtta M. Juenke, Rebecka Davis, and Gwendolyn A. McMillin
 
17. Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS
            Elizabeth R. Kiely and Heather M. Antonides
 
18. Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry
            Jennifer A. Collins and Gregory C. Janis
 
19. Therapeutic Drug Monitoring of Tamoxifen Using LC-MS/MS            Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

            Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu
            Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu
            Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu
            Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay
 
4. Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry
            Cynthia L. Morris-Kukoski, Jason E. Schaff, and Louis J. Reda
 
5. Opiate Screening and Quantitation in Urine/Blood Matrices using LC-MS/MS Techniques
            Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay
 
6. Synthetic Opioid Analysis by LC-MS/MS
            David M. Garby and Lynn A. Cheryk
 
7. The Determination of Cannabinoids Using Liquid Chromatography with Mass Spectrometric Detection
            Oscar Quintela and Dennis J. Crouch
 
8. Cocaine and Metabolites by LC-MS/MS
            Christine L. H. Snozek, Matthew W. Bjergum, and Loralie J. Langman
 
9. Quantitation of Amphetamine Type Stimulants by LC-MS/MS
            Robert A. Middleberg and Joseph Homan
 
10. Detection of Prohibited Subst