Stem Cell in Medicine

Erscheinungsjahr 2023
ISBN: 978-0-443-13411-1
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 151 mm x 229 mm, Gewicht: 820 g

**Association of American Publishers (AAP) PROSE Award Finalist in Biomedicine and Neuroscience, 2024** Stem Cells in Medicine, Volume 199 in the Progress in Molecular Biology and Translational Science series, provides the most topical and informative research in the field of stem cells. Sections in this new release update on an Introduction to stem cells, Stem cell engineering, Xeno-free culture and proliferation of hPSCs on 2D biomaterials, 3D scaffold preparation for stem cell culture and differentiation, GMP grade production of hPSCs, Human hepatic stem cell assay, Cardiomyocyte cell sheets derived from hPSCs and muscle cells for myocardial infarction treatment, Stem cell therapy for osteoarthritis, hPSC-derived RPE transplantation for the treatment of macular degeneration, and much more.

The book provides not only fundamental aspects and cultural and production methods of stem cells, but also the critical engineering aspects of stem cells such as drug screening using hepatocytes and disease treatment by transplantation of retinal pigment epithelium and cardiomyocytes which are derived from human pluripotent stem cells.

Autoren/Hrsg.

Weitere Mitwirkende

Higuchi, Akon

Zhou, Yinghong

Chiou, Shih-Hwa

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Biowissenschaften Molekularbiologie

Inhaltsverzeichnis

Preface

Akon Higuchi, Yinghong Zhou and Shih-Hwa Chiou

- Introduction to stem cells

Zeyu Tian, Tao Yu, Jun Liu, Ting Wang, and Akon Higuchi

- Engineered adult stem cells: current clinical trials status of disease treatment

Pingping Han, Corey Stephan Moran, Chun Liu, Rebecca Griffiths, Yinghong Zhou, and

Saso Ivanovski

- Xeno-free culture and proliferation of hPSCs on 2D biomaterials

Ting Wang, Tao Yu, Chang-Yen Tsai, Zhao-Yu Hong, Wen-Hui Chao, Yi-Shuo Su, Suresh Kumar Subbiah, Remya Rajan Renuka, Shih-Tien Hsu, Gwo-Jang Wu, and Akon Higuchi

- Stem cell culture and differentiation in 3-D scaffolds

Yasuhiko Tabata, Idaszek Joanna, and Akon Higuchi

- Current trends and promising clinical utility of IPSC-derived MSC (iMSC)

Shih-Hwa Chiou, Alan Han Kiat Ong, Shih-Jie Chou, Ahmed Faris Aldoghachi, Jit Kai Loh, Nalini Devi Verusingam,

Yi-Ping Yang, and Yueh Chien

- Drug metabolic activity as a selection factor for pluripotent stem cell-derived hepatic progenitor cells

Saeko Akiyama, Noriaki Saku, Shoko Miyata, Kenta Ite, Hidenori Nonaka, Masashi Toyoda, Akihide Kamiya, Tohru Kiyono, Tohru Kimura, Mureo Kasahara, and Akihiro Umezawa

- Cardiac cell sheet engineering for regenerative medicine and tissue modeling

Katsuhisa Matsuura and Tatsuya Shimizu

- Mesenchymal stem cells in osteoarthritis: The need for translation into clinical therapy

Feng Gao, Xinzhan Mao, and Xiaoxin Wu

- hPSC-derived RPE transplantation for the treatment of macular degeneration

Qian Liu, Jun Liu, and Akon Higuchi

- Universal and hypoimmunogenic pluripotent stem cells for clinical usage

Tzu-Cheng Sung, Kailibinuer Maitiruze, Jiandong Pan,

Jian Gong, Yongheng Bai, Xiaodong Pan, and Akon Higuchi

- Clinical Usage of Dental Stem Cells and Their Derived Extracellular Vesicles

Yinghong Zhou, Tian Xu, Cong Wang, Pingping Han, and Saso Ivanovski

- Vascularization of cutaneous wounds by stem cells

Motaharesadat Hosseini and Abbas Shafiee

- Application of IPSC and Müller glia derivatives in retinal degenerative diseases

Guoge Han, Pinghui Wei, and Quanhong Han

- Pluripotent Stem Cells as a Therapy for Type 1 Diabetes

Bernard E. Tuch, Iris S. Cheng, Hoang Phuc Dang, Hui Chen, and Tim R. Dargaville

- Stem cell challenges and opportunities

Kenta Ite, Masashi Toyoda, Saeko Akiyama, Shin Enosawa, Saeko Yoshioka,

Takaaki Yukitake, Mayu Yamazaki-Inoue, Kuniko Tatsumi, Hidenori Akutsu, Hiroshi Nishina, Toru Kimura, Naoko Otani, Atsuko Nakazawa, Akinari Fukuda, Mureo Kasahara, and Akihiro Umezawa

Über Autor(innen)

Chiou, Shih-Hwa
Prof. Shih-Hwa Chiou is a physician-scientist, the Director of Department of Medical Research in Taipei Veterans General Hospital, and distinguished Chair Professor in the Institute of Pharmacology and the Institute of Clinical Medicine & Genomic Center, of National Yang-Ming University in Taiwan. He had been trained in the Department of Molecular Biochemistry of The Boston Children Hospital of Harvard Medical School and the Department of Molecular Biochemistry of The Scripps Research Institute in USA as a visiting Researcher. He won the Young Investigator Award, in the Annual Meeting of Society of Molecular Imaging (Germany) and the Achievement Award of the Society of Asia-Pacific Academy of Ophthalmology (Australia). He was invited to be a Chairman & Keynote speaker at the Cancer Stem Cell Section in 69th Annual Meeting, Japan Cancer Association (JCA) in Japan. Currently, he devotes in using iPSC-derived 3D organoid as disease models for researches in genetic-mutation diseases, drug screening, and nanomedicine-based genomic editing technology in personalized medicine.

Zhou, Yinghong
Dr Yinghong Zhou is a Senior Research Fellow leading the Translational ImmunoEngineering for Regenerative Dentistry research team at the School of Dentistry, University of Queensland. Dr Zhou obtained her PhD in Biomedical Engineering from the Queensland University of Technology (QUT) in 2013. Dr Zhou seeks to understand the mechanisms for bone repair and regeneration, with a particular interest in stem cell-based therapy and biomaterial application. She has been awarded a prestigious NHMRC Early Career Fellowship (2016-2020) to investigate cell signalling cues involved in periodontal tissue regeneration, an Endeavour Research Fellowship (2017) for a collaborative project on cell transformation at Texas A&M University College of Dentistry, and a BridgeTech Program Fellowship (2021) to advance research towards commercialisation. Dr Zhou was appointed as the Coordinator of the Australia-China Centre for Tissue Engineering and Regenerative Medicine (ACCTERM) in 2013, then Deputy Director in 2016 and has worked in the role since.

Higuchi, Akon
Prof. Higuchi is a distinguished Professor in National Central University, a guest researcher in RIKEN (Japan) and National Research Center for Child Health and Development (Tokyo), and a visiting professor in King Saud University (Saudi Arabia) and Wenzhou Medical University (China). He received his Ph.D. in Tokyo Institute of Technology in 1985. He was a Professor in Seikei University (Tokyo) from 1993 to 2007. He received Sofue Memorial Award from Society of Fiber Science, Japan in 1994, Seikei Academic Award from Seikei Alumni Association in 2003, and Nanotechnology Outstanding Contribution Award, National Science Council, Taiwan in 2013, Future Tech Breakthrough Award in 2019, Ministry of Science and Technology, Taiwan. He also received Outstanding Scientific Award, Tissue Engineering and Regenerative Medicine International Society, Asia Pacific region (TERMIS-AP) in 2021. He is a fellow of Royal Society of Chemistry (RSC, England), a fellow of Taiwan Chemical Engineering Society, and a fellow of American Institute for Medical & Biological Engineering (AIMBE, USA). He is interested in the development of materials for stem cell culture and differentiation. He established purification method of hematopoietic stem cells and mesenchymal stem cells from umbilical cord blood and adipose tissue, respectively by filtration method through polymeric porous membranes. He is also developing biomaterials for stem cell culture and differentiation. He emphasized the important function of cell culture biomaterials, which guide differentiation fate of human pluripotent stem cells and mesenchymal stem cells into specific lineage of the cells. He developed ECM-derived peptide-immobilized hydrogels having adjustable elasticity for culture and differentiation of human pluripotent stem cells. He is now developing universal (hypoimmunogenic) human pluripotent stem cells on specific ECM-coated surface. He is an advisory board of Journal of Materials Chemistry B (RSC), an Editor of Open Physics, Editorial Board of Laboratory Investigation, Editorial Board of Tissue Engineering and Regenerative Medicine, and Associate Editor of IET Nanobiotechnology.