Trends in mRNA Vaccine Research

1. Auflage 2025
ISBN: 978-3-527-35058-2
Verlag: Wiley-VCH GmbH

Buch, Englisch, Band 1, 432 Seiten, Format (B × H): 172 mm x 255 mm, Gewicht: 960 g

Reihe: Trends in Drug Discovery

The authoritative guide to the revolutionary concept behind the successful Covid-19 vaccines In 'Trends in mRNA Vaccine Research', a team of distinguished researchers delivers a practical and up-to-date discussion of the biochemical and biomedical foundations of mRNA vaccines. They also explore the manufacturing conditions required for successful vaccine development and review recent progress in a variety of medical fields, including vaccines against pathogens like SARS-CoV-2, HIV, Plasmodium, Mycobacterium tuberculosis, as well as anticancer vaccines. Volume highlights include: - A historical overview of mRNA vaccine development - Immune responses to modified or unmodified mRNA vaccines - A description of the different mRNA vaccine platforms - Latest data on current mRNA vaccine developments against infectious diseases and cancer Perfect for medicinal chemists, immunologists, and epidemiologists, 'Trends in mRNA Vaccine Research' will also benefit researchers and scientists working in the pharmaceutical industry, as well as cancer researchers with an interest in vaccine development.

Autoren/Hrsg.

Szabo, Gabor Tamas

Pardi, Norbert

Weitere Mitwirkende

Fischer, János

Klein, Christian

Childers, Wayne E.

Fachgebiete

• Naturwissenschaften Chemie Chemie Allgemein Pharmazeutische Chemie, Medizinische Chemie
• Naturwissenschaften Biowissenschaften Zellbiologie
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Immunologie

Inhaltsverzeichnis

PART I: HOW mRNA VACCINES WORKA Historical Overview on mRNA Vaccine DevelopmentImmune Responses to mRNA VaccinesModified or Unmodified mRNA Vaccines? - The Biochemistry of Pseudouridine in mRNA VaccinesSelf-replicating RNA Viruses for Vaccine DevelopmentCircular RNA Therapeutics and VaccinesGMP and Up-scaling of mRNA Vaccine ProductionmRNA Vaccination for Induction of Immune Tolerance Against Autoimmune Disease PART II: RECENT PROGRESS IN VACCINE RESEARCH AND DEVELOPMENTApproved mRNA Vaccines Against SARS-CoV-2mRNA Vaccines for HIV-1mRNA Vaccines Against Tick-borne DiseasesmRNA Vaccines for Malaria and Other Parasitic PathogensmRNA Vaccines Against Mycobacterium tuberculosisCancer Vaccines Based on mRNA: Hype or Hope?

Über Autor(innen)

Gabor Tamas Szabo, MD, PhD, is an Associate Director at BioNTech SE. His work is focused on mRNA technology optimization and applications. Norbert Pardi, PhD, is an Assistant Professor at the University of Pennsylvania, USA. His research is focused on the development of mRNA-based therapeutics with a focus on vaccines.