Szabo / Pardi Trends in mRNA Vaccine Research

1. Auflage 2024
ISBN: 978-3-527-83838-7
Verlag: Wiley-VCH
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, Band 1, 754 Seiten, E-Book

Reihe: Trends in Drug Discovery

The authoritative guide to the revolutionary concept behind the successful Covid-19 vaccines In 'Trends in mRNA Vaccine Research', a team of distinguished researchers delivers a practical and up-to-date discussion of the biochemical and biomedical foundations of mRNA vaccines. They also explore the manufacturing conditions required for successful vaccine development and review recent progress in a variety of medical fields, including vaccines against pathogens like SARS-CoV-2, HIV, Plasmodium, Mycobacterium tuberculosis, as well as anticancer vaccines. Volume highlights include: - A historical overview of mRNA vaccine development - Immune responses to modified or unmodified mRNA vaccines - A description of the different mRNA vaccine platforms - Latest data on current mRNA vaccine developments against infectious diseases and cancer Perfect for medicinal chemists, immunologists, and epidemiologists, 'Trends in mRNA Vaccine Research' will also benefit researchers and scientists working in the pharmaceutical industry, as well as cancer researchers with an interest in vaccine development.

Autoren/Hrsg.

Szabo, Gabor Tamas

Pardi, Norbert

Weitere Mitwirkende

Fischer, János

Klein, Christian

Childers, Wayne E.

Inhaltsverzeichnis

PART I: HOW mRNA VACCINES WORK A Historical Overview on mRNA Vaccine Development Immune Responses to mRNA Vaccines Modified or Unmodified mRNA Vaccines? - The Biochemistry of Pseudouridine in mRNA Vaccines Self-replicating RNA Viruses for Vaccine Development Circular RNA Therapeutics and Vaccines GMP and Up-scaling of mRNA Vaccine Production mRNA Vaccination for Induction of Immune Tolerance Against Autoimmune Disease   PART II: RECENT PROGRESS IN VACCINE RESEARCH AND DEVELOPMENT Approved mRNA Vaccines Against SARS-CoV-2 mRNA Vaccines for HIV-1 mRNA Vaccines Against Tick-borne Diseases mRNA Vaccines for Malaria and Other Parasitic Pathogens mRNA Vaccines Against Mycobacterium tuberculosis Cancer Vaccines Based on mRNA: Hype or Hope?

Über Autor(innen)

Gabor Tamas Szabo, MD, PhD, is an Associate Director at BioNTech SE. His work is focused on mRNA technology optimization and applications.   Norbert Pardi, PhD, is an Assistant Professor at the University of Pennsylvania, USA. His research is focused on the development of mRNA-based therapeutics with a focus on vaccines.