?Theoretical and Clinical Geropharmacology?

Erscheinungsjahr 2025
ISBN: 978-0-443-34643-9
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm

This book explores the emerging field of senotherapeutics, which focuses on targeting cellular senescence to reduce age-related diseases and promote healthy aging. As the population ages, there is growing interest in developing senotherapeutic strategies to delay or reverse age-related degenerative processes. Senotherapeutics offers promising approaches to achieve this goal by addressing the key factors that drive cellular aging. Fundamental mechanisms of cellular senescence, the potential of senolytic and senomorphic compounds in integrating senescence-associated pathways, and their relevance in conventional geropharmacology are offered to the readers. The current volume also highlights recent advances, challenges, and future directions, emphasizing developing senotherapeutic medications to promote longevity and improve healthspan.

Autoren/Hrsg.

Weitere Mitwirkende

Can Atayik, Mehmet

Cakatay, Ufuk

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizinische Fachgebiete Pharmakologie, Toxikologie

Inhaltsverzeichnis

1. Senotherapeutics: Milestones, innovations, and future prospects
Ufuk Çakatay, Erdem Atasever and Mehmet Can Atayik
2. Game Changer: Navigating between challenges and hopes in Geropharmacology
Qian Chen, Lindon Young, Reid Hartman, Lidia Dankiv, Emily Yan and Robert Barsotti
3. Next-Gen Senotherapeutics: AI/ML-driven strategies for aging and age-related disorders
Kavitha Thirumurugan, Prashanth S. Javali, Subhajit Sarkar, Ashish Kumar, Sree Varshini R and Jose Mathew D
4. Pharmacological frontiers in senescence: Transforming senescence with drug repurposing:

Andleeb Shahzadi, Sibel Ozyazgan and Ufuk Çakatay
5. Pharmacological potential of calorie restriction mimetics in mitigating brain aging
Abhishek Kumar Singh
6. Isothiocyanates from cruciferous plants as geroprotectors
Volodymyr I. Lushchak
7. Cellular parabiosis as a senotherapeutic approach
Ilhan Onaran and Sevide Sencan
8. Molecular imaging for senescent cells-targeted therapeutics in aging and age-related diseases
Peili Cen
9. Mitochondria-associated membranes (MAMs) in age-related heart diseases, role of endoplasmic reticulum stress
Alejandro Silva-Palacios
10. Cellular senescence and senotherapeutics in cardiovascular diseases
Arttatrana Pal
11. Risk of senescence, polypharmacy, and their outcomes in elderly cardiovascular disease patients
Tamer Cebe and Fatih Kizilyel
12. Geropharmacology and gastrointestinal surgery
Anil Orhan
13. Oxygen-ozone adjunct therapy in aging and senescence-related disorders. State of art
Salvatore Chirumbolo, Giovanni Ricevuti, Marianno Franzini and Francesco Vaiano
14. Polypharmacy-induced changes in the oral mucosa and jawbone in elderly
Mehmet Yaltirik, Kaan Erisildar and Sabahat Zeynep Yey Özkeskin
15. Senotherapeutic approach to age-related endocrine diseases
Gülnur Andican and Seydanur Turgut
16. Polypharmacy as a reason for misinterpreting laboratory results in the elderly.
Ibrahim Murat Bolayirli

Über Autor(innen)

Cakatay, Ufuk
Ufuk Çakatay (May 09, 1965 -) is a Turkish biochemist and biogerontologist. He is a full professor of medical biochemistry at Istanbul-University Cerrahpasa in Istanbul, Turkey. He has a long-standing interest in oxidative protein damage, redox signaling, and biomarkers of proteostasis. Much less is known about the relationship between redox signaling events and senescent cells. However, it has been shown that the number of senescent cells in many tissues increases with age and that senescent cells are found in various age-related diseases. The development of experimental animal models for age-related disorders and the optimization of various bioanalytical techniques for the assessment of redox status in aging tissue are among his major research interests. Professor Çakatay has authored more than 100 publications in several leading journals, including research papers, book chapters, editorials, and invited reviews on free radical biology, aging, diabetes, redox signaling, and senotherapeutics. He has been a guest editor, reviewer, and editorial board member for more than 50 journals. In addition, Professor Çakatay has a keen interest in mentoring medical students and promoting their research careers. He has received several prestigious awards, including the Top Reviewer Award from Elsevier Science Publishing, and was a former member of the Animal Research and Ethics Committee of Istanbul University.

Can Atayik, Mehmet
Dr. Atayik is currently working in the Department of General Surgery at Hacettepe University Faculty of Medicine. He has been working as a scientist and researcher with Prof. Ufuk Çakatay since 2017. His research interests are in the fields of aging, age-related disorders, redox biology, oncogenetics, melatonin, mitochondria, surgical advances, and developing novel techniques for modern surgery. Dr. Atayik has conducted clinical research and experimental studies. He has published many scientific papers, such as research papers, narrative reviews, and book chapters, and has worked as an author, referee, editorial assistant, and guest editor, and editor in many prominent publishing houses. He was awarded the Young Investigator Presentation Prize at the VIII. International Congress of Molecular Medicine, which was held in Istanbul, Turkey, in November 2021.