Translational Bioinformatics

Erscheinungsjahr 2024
ISBN: 978-0-443-19348-4
Verlag: Elsevier Science & Technology

Buch, Englisch, Format (B × H): 152 mm x 229 mm, Gewicht: 450 g

Translational Bioinformatics is an emerging field in the direction of biomedical research. High throughput technologies can be applied to the generated biological data to develop the vaccine and personalized medicine. This volume consists of the chapters from different stalwart of the field covering the topics such as drug development, vector engineering, vaccine development and translational genomics. Chapters covered in this volume discuss the translational research related with cancer, Alzheimer disease and cardiovascular diseases. This volume includes the chapter describing the importance of computational resources and chemoinformatics for the translational health research. How Omics studies are helping to translate the laboratory data into the development of tools which are beneficial in the clinics have been described. How translational bioinformatics helpful in plant genomics to improve the crops have also been included in this volume. This volume has a chapter which describes the secrets of resistance development and further how these resistance are associated with human infectious diseases. This volume will be useful to the early career researcher in the development of research idea and develop their methodologies in the direction of bioinformatics and it will also give the insight to translate their findings.

Autoren/Hrsg.

Weitere Mitwirkende

Donev, Rossen

Prajapati, Vijay Kumar

Fachgebiete

• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)
• Naturwissenschaften Chemie Organische Chemie

Inhaltsverzeichnis

1. Genome to Clinic: The Power of Translational Bioinformatics in Improving Human Health
Vijay Kumar Prapajati
2. Computational approaches for identifying disease causing mutations in proteins
M. Michael Gromiha
3. Genome-based solutions for managing mucormycosis
Gajendra Pal Singh Raghava
4. Nanobioinformatics-based Insights into the Interaction of Blood Plasma Proteins with Carbon-Based Nanomaterials: Implications for Biomedical Applications
Sunil Kumar Singh
5. Computational Resources and Chemoinformatics: Accelerating Translational Health Research
Timir Tripathi and Dev Bukhsh Singh
6. Protein-Protein Interaction Network analysis for the Identification of Novel Multi-target inhibitors and target miRNAs against Alzheimer's disease
Kunal Roy
7. Engineering Immune Response to Regulate Cardiovascular Disease and Cancers
Sanjay Kumar Dey, Shahjahan Shahjahan and Joy Kumar Dey
8. circCodan: A ghmm-based tool for accurate prediction of Coding Regions in circRNA
Alexandre Paschoal and André Yoshiaki Kashibawara
9. Recent advances in plant translational genomics for crop improvement
Rajiv Ranjan
10. Uncovering the Secrets of Resistance: An Introduction to Computational Methods in Infectious Disease Research
Aditya K. Padhi and Shweata Maurya
11. Technological advances in the Design and Optimization of viral vectors for
Vijay Kumar Prapajati
12. A journey from Omics to Clinicomics in Cancer: Success Stories and Challenges
Sanjana Mehrotra

Über Autor(innen)

Donev, Rossen
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

Prajapati, Vijay Kumar
Dr. Vijay Kumar Prajapati is working as an Associate Professor at Department of Biochemistry, University of Delhi South Campus, New Delhi, India. He has extensive experience on Immunotherapy, antibody engineering and vaccine development for infectious diseases. He has published approx. 100 research articles in the international journal with >10 book chapters with reputed publishers. He is a recipient of prestigious INSA Medal for Young Scientist from Indian National Science Academy (INSA) and Associate from Indian Academy of Sciences, Benguluru. He has published research work in the prestigious journal such as Journal of Infectious Diseases, Clinical Infectious Diseases, Scientific Reports, Medicinal Research Review, Journal of Cellular Physiology etc. His current h-index is 41 with 5243 citations.