Witt / Linde Clinical Research in Complementary and Integrative Medicine

A Practical Training Book
1. Auflage 2011
ISBN: 978-3-437-59652-0
Verlag: Elsevier Health Science
Format: EPUB
Kopierschutz: Adobe DRM (»Systemvoraussetzungen)

E-Book, Englisch, 200 Seiten

You want to conduct a CAM study but don't know how?  Problem solved - Clinical Research demonstrates all aspects of state-of-the-art study design in an understandable and practical way. You will get a comprehensive overview and instruction - step by step.This practical training book: systematically introduces the key aspects of study design and basic statistics.helps you to develop, plan and execute your research project.combines established theoretical approaches with practical skills applicable to your own clinical study.is a step-by-step tutorial for a complete clinical study, which is illustrated in three case studies.includes additional training exercises, featuring different study conditions and environments, that will help you to practice and test your knowledge. Clinical Research in Complementary and Integrative Medicine - the best way to understand clinical research and to plan and perform your own study!

Autoren/Hrsg.

Witt, Claudia M.

Witt, Claudia

Linde, Klaus

Inhaltsverzeichnis

1;Front Cover;1
2;Clinical Research in Complementary and Integrative Medicine;4
3;Copyright;5
4;Preface;6
5;We would like to thank;7
6;Glossary;8
7;Contents;12
8;KAPITEL 1 - Introduction;16
8.1;1.1 What do we mean by complementary medicine in this book?;16
8.2;1.2 The science behind clinical medicine;17
8.3;1.3 Why do we need research on complementary therapies?;18
8.4;1.4 Is research into complementary therapies special?;20
8.5;1.5 Aims, target audience and structure of this book;22
9;I - Theory – Things you should know before embarking on a clinical study;24
9.1;KAPITEL 2 - Basic study design;26
9.1.1;2.1 When is a treatment effective?;26
9.1.2;2.2 Bias – threats to internal validity;30
9.1.3;2.3 Clinical studies and the real world – external validity;33
9.1.4;2.4 What study design for what purpose?;37
9.1.5;2.5 Establishing an evidence picture;46
9.2;KAPITEL 3 - Basic statistics;48
9.2.1;3.1 Why statistics?;48
9.2.2;3.2 Types of variables and their distribution;48
9.2.3;3.3 Summarizing your data;49
9.2.4;3.4 Comparing two groups or two time points for one variable;53
9.2.5;3.5 Comparing more than two groups for one variable;59
9.2.6;3.6 Comparing two or more groups for more than one variable;60
9.2.7;3.7 Analysis populations;61
9.2.8;3.8 Dealing with missing values;61
9.2.9;3.9 Interval hypotheses: equivalence/non-inferiority and superiority;62
10;II - Practice – Planning, managing, analyzing and publishing a clinical study;64
10.1;KAPITEL 4 - Planning;66
10.1.1;4.1 Formulating the research question;66
10.1.2;4.2 Study Protocol;71
10.1.3;4.3 Interventions and Controls;74
10.1.4;4.4 Randomization;80
10.1.5;4.5 What to do if you do not randomize;86
10.1.6;4.6 Blinding;89
10.1.7;4.7 Study participants;96
10.1.8;4.8 Outcome measurement;100
10.1.9;4.9 Sample size calculation;108
10.1.10;4.10 Ethics and regulatory aspects;117
10.2;KAPITEL 5 - Study and data management;120
10.2.1;5.1 Project management;120
10.2.2;5.2 Guidelines for clinical trials;121
10.2.3;5.3 Study management;122
10.2.4;5.4 Data management;128
10.2.5;5.5 Case studies;136
10.3;KAPITEL 6 - Data analysis;138
10.3.1;6.1 Analysing your own data step by step;138
10.3.2;6.2 Case studies;142
10.4;KAPITEL 7 - Publication;148
10.4.1;7.1 General issues;148
10.4.2;7.2 Early preparatory work;149
10.4.3;7.3 Writing the manuscript;152
10.4.4;7.4 Getting your manuscript accepted;156
10.4.5;7.5 After acceptance;159
11;III - Putting a clinical study into context;160
11.1;KAPITEL 8 - Qualitative research;162
11.1.1;8.1 Research question and examples;162
11.1.2;8.2 Qualitative approaches;163
11.1.3;8.3 Qualitative methods and types of data;164
11.1.4;8.4 Qualitative data analysis;165
11.1.5;8.5 Quality assurance in qualitative research;166
11.1.6;8.6 Combining qualitative and quantitative research methods;166
11.2;KAPITEL 9 - Economic studies;168
11.2.1;9.1 Principles of economic analysis;168
11.2.2;9.2 Types of economic evaluations;171
11.2.3;9.3 Examples of economic analysis;173
11.2.4;9.4 Critical appraisal;174
11.3;KAPITEL 10 - Single-case research ;178
11.3.1;10.1 Why case reports are not scientific;178
11.3.2;10.2 Why single-case research is important;178
11.3.3;10.3 Assessing causality in single cases;179
11.3.4;10.4 Experimental single-case studies;179
11.3.5;10.5 Observational single case studies;183
11.3.6;10.6 Cross-roads between research on single cases and groups of patients;184
11.4;KAPITEL 11 - A brief look at other study designs;188
11.4.1;11.1 Cross-sectional studies/surveys;188
11.4.2;11.2 Diagnostic studies;190
11.4.3;11.3 Etiological and prognostic studies;192
12;Appendix;196
13;Index;202