Wood Neuroinflammation

Mechanisms and Management
Erscheinungsjahr 1997
ISBN: 978-1-59259-473-3
Verlag: Humana Press
Format: PDF
Kopierschutz: 1 - PDF Watermark

E-Book, Englisch, 375 Seiten, eBook

Reihe: Contemporary Neuroscience

An unprecedented review of our current knowledge of the neuroinflammatory mediators and cells involved in neurodegenerative diseases. Beginning with a detailed review of our current concepts of which biochemical mediators are involved in neuronal loss and the mechanisms of cell death, the distinguished contributors critically examine those areas of current research involved in the design of specific pharmacological agents to inhibit at defined points in the neuroinflammatory cascade. They also address the molecular, cellular, and disease model actions of first-generation agents, as well as the potential clinical relevance to AIDS-related dementia, Alzheimer's disease, amyotropic lateral sclerosis (ALS), Down's syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and stroke.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Wood, Paul L.

Inhaltsverzeichnis

I. Microglia.- 1 Roles of CNS Macrophages in Neurodegeneration.- 2 Inflammatory Markers in Chronic Neurodegenerative Disorders, with Emphasis on Alzheimer’s Disease.- 3 Inflammatory Markers in Stroke.- 4 Microgliosis and Impaired Cognition.- II. Acute Phase Proteins.- 5 Strategies for Inhibition of Complement Activation in the Treatment of Neurodegenerative Diseases.- 6 Inflammatory Mechanisms of Alzheimer’s Disease: Basic Research, Clinical Studies, and Future Directions.- III. Cytokines.- 7 Role of IL-1 in Neurodegeneration: Preclinical Findings with IL-1ra and ICE Inhibitors.- 8 Cytokines in Severe Head Injury.- 9 Neuroimmune Mechanisms in the Treatment of Multiple Sclerosis.- IV. Free Radicals.- 10 Reactive Oxygen Involvement in Neurodegenerative Pathways: Causes, Consequences, and Potential Management with Nitrone-Based Free Radical Traps.- 11 Utility of the 21-Aminosteroids in Spinal Cord Injury.- V. Miscellaneous Mediators.- 12 The Role of Cell-Adhesion Molecules in NeurologicalDisorders.- 13 The Role of Glial Nitric Oxide in Neurotoxicity and Central Nervous System Diseases.- 14 Inducible Cyclooxygenase (COX-2): A Target for Novel Anti-Inflammatory Drugs.