The Biology of mRNA: Structure and Function

1. Auflage 2019
ISBN: 978-3-030-31436-1
Verlag: Springer International Publishing

Buch, Englisch, Band 1203, 312 Seiten, Format (B × H): 155 mm x 235 mm, Gewicht: 555 g

Reihe: Advances in Experimental Medicine and Biology

The book provides an overview on the different aspects of gene regulation from an mRNA centric viewpoint, including how mRNA is assembled and self-assembles in a complex consisting of RNA and proteins, and how its ability to be translated at the right time and space depends on many processes acting on the mRNAs, leading to a properly folded complex. This book shows how new technologies have led to a better understanding of these processes and their connected diseases.The book is written for scientists in fundamental and applied biomedical research working on different aspects of gene regulation. It is also targeted to an audience that is not implicated in these fields directly, but wants to gain a better understanding of mRNA biology.

Zielgruppe

Research

Autoren/Hrsg.

Zenklusen, Daniel

Oeffinger, Marlene

Fachgebiete

• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Klinische und Innere Medizin Neurologie, Klinische Neurowissenschaft
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Molekulare Medizin, Zellbiologie
• Naturwissenschaften Biowissenschaften Proteinforschung
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Vorklinische Medizin: Grundlagenfächer Humangenetik
• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Neurowissenschaften, Kognitionswissenschaft

Inhaltsverzeichnis

Regulation of co-transcriptional mRNP assembly.- mRNA export through the NPC.- Roles of mRNA modifications in gene regulation.- Studying mRNPs using single molecule approaches.- Difference between mRNPs and lncRNAs?.- RNPs and/or sequence motives in mRNA localization.- mRNP structure.- New RNA binding proteins: mRNP composition.- Aggregation of repeats RNAs in neurodegenerative diseases.- mRNA structural organization and translation.- How to decide to make an mRNA - degradation.- Methods to study mRNP composition.- mRNA-DNA kisses – R-loops.- Forms of mRNA editing and their role in disease.

Über Autor(innen)

Marlene Oeffinger is Associate Research Professor at the Institut de recherches cliniques de Montréal (IRCM) and the Department of biochemistry and molecular medicine at the Université de Montréal in Montréal, Canada, and Adjunct Professor in the Division of Experimental Medicine at McGill University. Her laboratory uses Proteomic, RNomic and biochemical approaches to study the regulation, dynamics and functional niches of RNA maturation pathways and their implications in neurodegenerative diseases.

Daniel Zenklusen is an Associate Professor at the Department of biochemistry and molecular medicine at the Université de Montréal in Montréal, Canada. His laboratory uses single molecule and super-resolution microscopy approaches to study different aspects of gene expression in single cells, including RNA transport and localization, lncRNAs function and mRNP organization.