Folate and Human Development

2002
ISBN: 978-0-89603-936-0
Verlag: Humana Press

Buch, Englisch, 359 Seiten, Format (B × H): 160 mm x 241 mm, Gewicht: 1550 g

An authoritative panel of basic and clinical researchers critically reviews the latest findings on the role of folate in human development, health, and disease. Specific areas addressed include folate metabolism in zinc or copper deficiencies, choline and folate in development, animal models of folate-related birth defects, developmental toxicants potentially acting via folate perturbation, and folate's role in vascular disease in women. There are also cutting-edge discussions of genes and neural tube development, folate receptor polymorphism and the risk for neural defects, abnormal DNA synthesis and methylation with folate/methyl insufficiency, and folic acid and homocysteine as risk factors for neural tube defects.

Zielgruppe

Professional/practitioner

Autoren/Hrsg.

Rogers, John M.

Massaro, Edward J.

Fachgebiete

• Interdisziplinäres Wissenschaften Wissenschaften Interdisziplinär Ökotrophologie (Ernährungs- und Haushaltswissenschaften)
• Medizin | Veterinärmedizin Medizin | Public Health | Pharmazie | Zahnmedizin Medizin, Gesundheitswesen Ernährungsmedizin, Diätetik
• Naturwissenschaften Biowissenschaften Biochemie (nichtmedizinisch)

Inhaltsverzeichnis

1 • Animal Models of Folate-Related Neural Tube Defects.- 2 • Genetic Variation in Folate Metabolism: Impacton Development.- 3 • Folate Deficiency and the Molecular Determinants of Chromosome Instability: Possible Link to Meiotic Nondisjunction and Down Syndrome.- 4 • Folic Acid, Vitamin B12, and Genomic Stability of Human Cells.- 5 • Molecular Genetics of Folate Metabolism.- 6 • Folate Receptor-?: An Update.- 7 • Folate, Homocysteine, and Neural Tube Defects.- 8 • Folic Acid and Homocysteine as Risk Factors for Neural Tube Defects.- 9 • Developmental Toxicants Potentially Acting via Folate Perturbation.- 10 • Brain Development and Choline, the Other Methyl Donor.- 11 • Nutrient Interactions Between Folate and Zinc or Copper: Their Possible Implications to Pregnancy Outcome.- 12 • Regulation of Folate Metabolism by Iron.- 13 • A Differential Role for Folate in Developmental Disorders, Vascular Disease, and Other Clinical Conditions: The Importance of Folate Status and Genotype.- 14 • Vascular Disease in Women: Folate and Homocysteine.- 15 • Folate, Homocysteine, and Cardiovascular Disease.